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KMID : 0381019930260070887
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Korean Journal of Nutrition
1993 Volume.26 No. 7 p.887 ~ p.898
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Effect of Iron Deficiency on the Capacity for Peroxisomal and Mitochondrial β-oxidation
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Swan, Patricia B
Chang Kyung-Ja
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Abstract
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In order to determine the effect of iron depletion and subsequent supplementation on the muscle capacity for peroxisomal (PO ) and mitochondrial (M O ) (3-oxidation during high fat feeding, weanling rats were fed a 44% (HF ) or 25% (LF) fat diet with C + Fe) or withoul (-Fc) iron for 6 or 9 weeks. After 1 week rats fed HF+Fe or H F -Fe had 50? 100% more PO and M O in heart soleus, psoas and gastrocnemius than did rats fed low faㄴ but after 3 weeks rats fed H F-Fe had lower muscle PO and MO . In muscles of iron depleted rats PO and M O were not increased by supplementation with iron for
3 weeks. After 6 weeks M O and PO in skeletal muscles of rats fed HF+Fe were lower than after 3 weeks. It is concluded that adequate iron is necessary for maximum response of muscle PO and M O to high fat feeding. However, after 6 weeks both PO and M O have returned to levels similar to those of rals fed low fat diets, hence, the elevated catalase
aclivilics seen at this time do not reflect peroxisomal (3-oxidation.
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KEYWORD
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iron deficiency, faiiy acid oxidation, peroxisome - catalase, skeletal muscle
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